Manchester United pair Luke Shaw and Henrikh Mkhitaryan could return from illness and injury respectively.
Phil Jones remains absent with a knee problem, while Wayne Rooney is pushing for a starting spot after impressing off the bench on Thursday.
Stoke midfielder Joe Allen has not trained since last weekend due to a tight hamstring and is a doubt.
Forward Jon Walters could return after an ankle injury but goalkeeper Jack Butland remains sidelined.
Manchester United manager Jose Mourinho: “It is another poisoned gift because Stoke is not what the table says. The manager is very good, the players are good, the team is good, so when I look to the table, that’s not Stoke’s position.
“I play against a good Stoke and not the Stoke in that position in the table.”
Stoke City manager Mark Hughes: “We think it’s only a matter of time before it comes because we’re not playing badly. The last two games I’ve seen a confident team, a team that wants to address the situation and get the maximum points.
“It’s not as if our confidence has been affected, we’re fine in that regard, but clearly we want to get three points on the board as quickly as possible.
“It’s going to be difficult this weekend because clearly our record at Manchester United isn’t great. It’s a big ask but, if we’re going to get a first win on the board, why can’t it be at Old Trafford?”
Credits: BBC Sport