GlaxoSmithKline’s first batch of experimental Ebola vaccines will arrive Liberia Friday, a statement from the British drugmaker revealed.
An initial 300 vials of the vaccine, will be used in the first large-scale vaccine trials in coming weeks, in which healthcare workers helping to care for Ebola patients will be among the first to get it.
“The initial phase I data … are encouraging and give us confidence to progress to the next phases of clinical testing which will involve the vaccination of thousands of volunteers, including frontline healthcare workers,” said Moncef Slaoui, GSK’s Global Vaccines chief.
The vaccine uses a type of chimpanzee cold virus to deliver safe genetic material from the Zaire strain of Ebola, the strain responsible for the unprecedented West African epidemic.
Data so far show “an acceptable safety profile” including in a West African population and across a range of dose levels, GSK said, adding it had now selected the most appropriate dosage for the Liberia trial.
The World Health Organization said on Thursday the Ebola outbreak in West Africa appears to be waning but cautioned against complacency in an epidemic that has seen 21,724 cases reported in nine countries since it started in Guinea a year ago. Some 8,641 people have died, according to WHO data.
Slaoui stressed that GSK’s shot, like other candidates from a NewLink Genetics and Merck collaboration, and from Johnson & Johnson and Bavarian Nordic, is still in development and can’t be deployed unless and until it proves safe and effective.
“Any potential future use in mass vaccination campaigns will depend on whether the WHO, regulators and other stakeholders are satisfied … and how quickly large quantities … can be made,” he said.